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- mRNA-based COVID shots have used codon optimization to improve protein production. A codon consists of three nucleotides, and nucleotides are the building blocks of DNA. Use of codon optimization virtually guarantees unexpected results
- Replacing rare codons must be done judiciously, as rarer codons can have slower translation rates and a slowed-down rate is actually necessary to prevent protein misfolding
- Stop codons, when present at the end of an mRNA coding sequence, signals the termination of protein synthesis. According to a recent paper, both Pfizer and Moderna selected suboptimal stop codons
- The COVID shots induce spike protein at levels unheard of in nature, and the spike protein is the toxic part of the virus responsible for the most unique effects of the virus, such as the blood clotting disorders, neurological problems and heart damage. To expect the COVID shot to not produce these kinds of effects would be rather naïve
- Other significant threats include immune dysfunction and the flare-up of latent viral infections such as herpes and shingles. Coinfections, in turn, could accelerate other diseases. Herpes viruses, for example, have been implicated as a cause of both AIDS and chronic fatigue syndrome
From Dr. Joseph Mercola
Since COVID-19 first entered the scene, exchange of ideas has basically been outlawed. By sharing my views and those from various experts throughout the pandemic on COVID treatments and the experimental COVID jabs, I became a main target of the White House, the political establishment and the global cabal.
Propaganda and pervasive censorship have been deployed to seize control over every part of your life, including your health, finances and food supply. The major media are key players and have been instrumental in creating and fueling fear.
I am republishing this article in its original form so that you can see how the progression unfolded.
Originally published: September 7, 2021
"Let's start with a thought experiment: If an engineering design flaw exists and no one measures it, can it really injure people or kill them?" a Twitter user named Ehden writes.1 He goes on to discuss an overlooked aspect of the COVID mRNA shots, something called "codon optimization," which virtually guarantees unexpected results. Ehden explains:2
"Trying to tell your body to generate proteins is hard for many reasons. One of them is the fact that when you try to run the protein information via ribosomes which process that code and generate the protein, it can be very slow or can get stuck during the process.
Luckily, scientists found a way to overcome this problem, by doing code substitution: instead of using the original genetic code to generate the protein, they changed the letters in the code so the code would be optimized. This is known as Codon Optimization."
COVID Shots Use Codon Optimization
A codon consists of three nucleotides, and nucleotides are the building blocks of DNA. An August 2021 article in Nature Reviews Drug Discovery, addressed the use of codon optimization as follows:3
"The open reading frame of the mRNA vaccine is the most crucial component because it contains the coding sequence that is translated into protein.
Although the open reading frame is not as malleable as the non-coding regions, it can be optimized to increase translation without altering the protein sequence by replacing rarely used codons with more frequently occurring codons that encode the same amino acid residue.
For instance, the biopharmaceutical company CureVac AG discovered that human mRNA codons rarely have A or U at the third position and patented a strategy that replaces A or U at the third position in the open reading frame with G or C. CureVac used this optimization strategy for its SARS-CoV-2 candidate CVnCoV …
Although replacement of rare codons is an attractive optimization strategy, it must be used judiciously. This is because, in the case of some proteins, the slower translation rate of rare codons is necessary for proper protein folding.
To maximize translation, the mRNA sequence typically incorporates modified nucleosides, such as pseudouridine, N1-methylpseudouridine or other nucleoside analogues. Because all native mRNAs include modified nucleosides, the immune system has evolved to recognize unmodified single-stranded RNA, which is a hallmark of viral infection.
Specifically, unmodified mRNA is recognized by pattern recognition receptors, such as Toll-like receptor 3 (TLR3), TLR7 and TLR8, and the retinoic acid-inducible gene I (RIGI) receptor. TLR7 and TLR8 receptors bind to guanosine- or uridine-rich regions in mRNA and trigger the production of type I interferons, such as IFNα, that can block mRNA translation.
The use of modified nucleosides, particularly modified uridine, prevents recognition by pattern recognition receptors, enabling sufficient levels of translation to produce prophylactic amounts of protein.
Both the Moderna and Pfizer–BioNTech SARS-CoV-2 vaccines … contain nucleoside-modified mRNAs. Another strategy to avoid detection by pattern recognition receptors, pioneered by CureVac, uses sequence engineering and codon optimization to deplete uridines by boosting the GC content of the vaccine mRNA."
Much of this information was previously reviewed in my interview with Stephanie Seneff, Ph.D., and Judy Mikovits, Ph.D. You can't see the article but the video is embedded above. This study was published well after our interview and merely confirms what Seneff and Mikovits have unraveled in their research.
According to Ehden, 60.9% of the codons in COVID shots have been optimized, equivalent to 22.5% of the nucleotides, but he doesn't specify which shot he's talking about, or exactly where the data came from.
That all mRNA COVID shots are using codon optimization to one degree or another is clear, however. A July 2021 article4 in the journal Vaccines specifically evaluates and comments on the Pfizer/BioNTech and Moderna mRNA shots, noting:
"The design of Pfizer/BioNTech and Moderna mRNA vaccines involves many different types of optimizations … The mRNA components of the vaccine need to have a 5′-UTR to load ribosomes efficiently onto the mRNA for translation initiation, optimized codon usage for efficient translation elongation, and optimal stop codon for efficient translation termination.
Both 5′-UTR and the downstream 3′-UTR should be optimized for mRNA stability. The replacement of uridine by N1-methylpseudourinine (Ψ) complicates some of these optimization processes because Ψ is more versatile in wobbling than U. Different optimizations can conflict with each other, and compromises would need to be made.
I highlight the similarities and differences between Pfizer/BioNTech and Moderna mRNA vaccines and discuss the advantage and disadvantage of each to facilitate future vaccine improvement. In particular, I point out a few optimizations in the design of the two mRNA vaccines that have not been performed properly."
What Can Go Wrong?
One key take-home from the Nature Reviews Drug Discovery article5 cited above is that replacing rare codons "must be used judiciously," as rarer codons can have slower translation rates and a slowed-down rate is actually necessary to prevent protein misfolding.
A (adenine) and U (uracil) in the third position are rare, and the COVID shots replace these A's and U's with G's (guanine) or C's (cytosine). According to Seneff, this switch results in a 1,000-fold greater amount of spike protein compared to being infected with the actual virus.
What could go wrong? Well, just about anything. Again, the shot induces spike protein at levels unheard of in nature (even if SARS-CoV-2 is a "souped up" manmade concoction), and the spike protein is the toxic part of the virus responsible for the most unique effects of the virus, such as the blood clotting disorders, neurological problems and heart damage.
So, to expect the COVID shot to not produce these kinds of effects would be rather naïve. The codon switches might also result in protein misfolding, which is equally bad news. As explained by Seneff in our previous interview:
"The spike proteins that these mRNA vaccines are producing … aren't able to go into the membrane, which I think is going to encourage it to become a problematic prion protein. Then, when you have inflammation, it upregulates alpha-synuclein [a neuronal protein that regulates synaptic traffic and neurotransmitter release].
So, you're going to get alpha-synuclein drawn into misfolded spike proteins, turning into a mess inside the dendritic cells in the germinal centers in the spleen. And they're going to package up all this crud into exosomes and release them. They're then going to travel along the vagus nerve to the brainstem and cause things like Parkinson's disease.
So, I think this is a complete setup for Parkinson's disease … It's going to push forward the date at which someone who has a propensity towards Parkinson's is going to get it.
And it's probably going to cause people to get Parkinson's who never would have gotten it in the first place — especially if they keep getting the vaccine every year. Every year you do a booster, you bring the date that you're going to get Parkinson's ever closer."
Immune Dysfunction and Viral Flare-Ups
Other significant threats include immune dysfunction and the flare-up of latent viral infections, which is something Mikovits has been warning about. In our previous interview, she noted:
"We use poly(I:C) [a toll-like receptor 3 agonist] to signal the cell to turn on the type I interferon pathway, and because [the spike protein your body produces in response to the COVID shot] is an unnatural synthetic envelope, you're not seeing poly(I:C), and you're not [activating] the Type I interferon pathway.
You've bypassed the plasmacytoid dendritic cell, which combined with IL-10, by talking to the regulatory B cells, decides what subclasses of antibodies to put out. So, you've bypassed the communication between the innate and adaptive immune response. You now miss the signaling of the endocannabinoid receptors …
A large part of Dr. [Francis] Ruscetti's and my work over the last 30 years has been to show you don't need an infectious transmissible virus — just pieces and parts of these viruses are worse, because they also turn on danger signals. They act like danger signals and pathogen-associated molecular patterns.
So, it synergistically leaves that inflammatory cytokine signature on that spins your innate immune response out of control. It just cannot keep up with the myelopoiesis [the production of cells in your bone marrow]. Hence you see a skew-away from the mesenchymal stem cell towards TGF-beta regulated hematopoietic stem cells.
This means you could see bleeding disorders on both ends. You can't make enough firetrucks to send to the fire. Your innate immune response can't get there, and then you've just got a total train wreck of your immune system."
We're now seeing reports of herpes and shingles infection following COVID-19 injection, and this is precisely what you can expect if your Type I interferon pathway is disabled. That's not the end of your potential troubles, however, as these coinfections could accelerate other diseases as well.
For example, herpes viruses have been implicated as a trigger of both AIDS6 and myalgic encephalomyelitis7 (chronic fatigue syndrome or ME-CFS). According to Mikovits, these diseases don't appear until viruses from different families partner up and retroviruses take out the Type 1 interferon pathway. Long term, the COVID mass injection campaign may be laying the foundation for a rapidly approaching avalanche of a wide range of debilitating chronic illnesses.
Are COVID Shots Appropriately Optimized?
As noted in the Vaccines article cited earlier, the codon optimization in the Pfizer and Moderna shots could be problematic:8
"As mammalian host cells attack unmodified exogeneous RNA, all U nucleotides were replaced by N1-methylpseudouridine (Ψ). However, Ψ wobbles more in base-pairing than U and can pair not only with A and G, but also, to a lesser extent, with C and U.
This is likely to increase misreading of a codon by a near-cognate tRNA. When nucleotide U in stop codons was replaced by Ψ, the rate of misreading of a stop codon by a near-cognate tRNAs increased.
Such readthrough events would not only decrease the number of immunogenic proteins, but also produce a longer protein of unknown fate with potentially deleterious effects …
The designers of both vaccines considered CGG as the optimal codon in the CGN codon family and recoded almost all CGN codons to CGG … [M]ultiple lines of evidence suggest that CGC is a better codon than CGG. The designers of the mRNA vaccines (especially mRNA-1273) chose a wrong codon as the optimal codon."
The paper also points out the importance of vaccine mRNA to be translated accurately and not merely effectively, because if the wrong amino acids are incorporated, it can confuse your immune system and prevent it from identifying the correct targets.
Accuracy is also important in translation termination, and here it comes down to selecting the correct stop codons. Stop codons (UAA, UAG or UGA), when present at the end of an mRNA coding sequence signals the termination of protein synthesis.
According to the author, both Pfizer and Moderna selected less than optimal stop codons. "UGA is a poor choice of a stop codon, and UGAU in Pfizer/BioNTech and Moderna mRNA vaccines could be even worse," she says.
What Health Problems Can We Expect to See More Of?
While the variety of diseases we may see a rise in as a result of this vaccination campaign are myriad, some general predictions can be made. We've already seen a massive uptick in blood clotting disorders, heart attacks and stroke, as well as heart inflammation.
More long term, Seneff believes we'll see a significant rise in cancer, accelerated Parkinson's-like diseases, Huntington's disease, and all types of autoimmune diseases and neurodegenerative disorders.
Mikovits also suspects many will develop chronic and debilitating diseases and will die prematurely. At highest risk, she places those who are asymptomatically infected with XMRVs and gammaretroviruses from contaminated conventional vaccines. The COVID shot will effectively accelerate their death by crippling their immune function. "The kids that are highly vaccinated, they're ticking time bombs," Mikovits said in my May 2021 interview.
What Are the Options?
While all of this is highly problematic, there is hope. From my perspective, I believe the best thing you can do is to build your innate immune system. To do that, you need to become metabolically flexible and optimize your diet. You'll also want to make sure your vitamin D level is optimized to between 60 ng/mL and 80 ng/mL (100 nmol/L to 150 nmol/L).
I also recommend time-restricted eating, where you eat all your meals for the day within a six- to eight-hour window. Time-restricted eating will also upregulate autophagy, which may help digest and remove spike protein. Avoid all vegetable oils and processed foods. Focus on certified-organic foods to minimize your glyphosate exposure.
Sauna therapy may also be helpful. It upregulates heat shock proteins, which can help refold misfolded proteins. They also tag damaged proteins and target them for removal.
Think Globally, Act Locally
National vaccine policy recommendations in the U.S. are made at the federal level but vaccine laws are made at the state level. It is at the state level where your action to protect your vaccine choice rights can have the greatest impact.
It is critical for EVERYONE to get involved now in standing up for the legal right to make voluntary vaccine choices in America because those choices are being seriously threatened.
Not only are lobbyists representing drug companies, medical trade associations and public health officials trying to persuade legislators to strip all vaccine exemptions from public health laws, but global political operatives lobbying the United Nations and World Health Organization are determined to take away the human right to autonomy and protection of bodily integrity.
We must take action to defend our constitutional republic and civil liberties, including the right to autonomy, in America. That includes reforming oppressive mandatory vaccination laws and stopping the digital health ID that will make vaccine passports a reality for us, our children and grandchildren if we don't take action today.
Signing up to use the free online Advocacy Portal sponsored by the National Vaccine Information Center at www.NVICAdvocacy.org gives you immediate, easy access to your own state and federal legislators on your smartphone or computer so you can make your voice heard.
NVIC will keep you up to date on the latest bills threatening to eliminate — or expand — your legal right to make vaccine choices and give you guidance about what you can do to support or oppose those bills. So, please, as your first step, sign up for the NVIC Advocacy Portal.
Share Your Story With Your Legislators and People You Know
If you or a family member has suffered a serious vaccine reaction, injury or death, please talk about it. If we don't share information and experiences with one another, everybody feels alone and afraid to speak up.
If you want to protect your legal right to say "no" to vaccines you do not believe are safe or effective, make an appointment to personally talk with someone you have elected to office at the local, state and federal level or write a letter in your own words stating your concerns.
Attend school board and city council and town hall meetings in your community that will impact your right to know and freedom to make decisions about how you or your children will live and stay healthy. If you have a different perspective on a story about vaccination that appears in your local newspaper, write a letter to the editor.
I must be frank with you: You have to be brave because there is a lot of censorship of conversations that challenge "official" narratives about vaccination. You likely will be strongly criticized for daring to talk about the "other side" of the vaccine story and for defending your informed consent rights. Be prepared for it and have the courage to stand your ground.
Only by sharing our perspective and what we know to be true will the public conversation about vaccination open up so people are not afraid to talk about it.
While our rights are being threatened, the vaccine injured are being swept under the carpet and treated like nothing more than statistically acceptable "collateral damage" of one-size-fits-all mandatory vaccination laws. Way too many people are being put at risk for injury and death and there is nothing scientific or moral about that. We should not be treating human beings like guinea pigs.
Internet Resources Where You Can Learn More
I encourage you to visit the four websites of the National Vaccine Information Center (NVIC), at www.NVIC.org, a nonprofit charity that has been educating the public about the need to prevent vaccine injuries and deaths since 1982. The information you get on their websites is fully referenced and will help you become an effective vaccine choice advocate in your community:
- NVIC.org — This website was established in 1995 and is the oldest and largest consumer operated website publishing information on diseases and vaccines on the internet. Learn about vaccine reactions, injuries and deaths and the history and current status of vaccine science, policy, law and ethics in the U.S. on more than 2,000 web pages.
- NVICAdvocacy.org — This communications and advocacy network, established in 2010, is your gateway to taking action to protect your right to make vaccine choices where you live.
- TheVaccineReaction.org — This weekly journal newspaper published by NVIC since 2015 is dedicated to encouraging an "enlightened conversation about vaccination, health and autonomy."
- MedAlerts.org — This is a user-friendly search engine for the federal Vaccine Adverse Event Reporting System (VAERS) established under the 1986 National Childhood Vaccine Injury Act and sponsored by NVIC since 2006. Search for descriptions of vaccine injuries and deaths reported to VAERS on this popular website.
Find A Doctor Who Will Listen and Care
If your doctor or pediatrician refuses to provide medical care to you or your child unless you agree to get vaccines you don't want, I strongly encourage you to have the courage to find another doctor. Harassment, coercion and refusal to provide medical care to someone declining one or more doses of government recommended vaccines is a violation of the informed consent ethic.
Unfortunately, it is becoming routine among members of the medical establishment to be reluctant to share vaccine decision-making power with patients and parents of minor children, especially during the aggressive push for all Americans to get COVID shots.
There are doctors out there who respect the precautionary and informed consent principles, so take the time to locate a doctor who treats you with compassion and is willing to listen and respect the health care choices you make for yourself or your child.